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KMID : 0665220140270010043
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Korean Journal of Food and Nutrition
2014 Volume.27 No. 1 p.43 ~ p.49
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Effects of Extract from Fermented Flower-buds of Panax ginseng C.A. Meyer on Mouse Cytokine IL-6, TNF-α Production
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Jeong Su-Ji
Kim Kyoung-Hee
Son Hwa-Young
Yook Hong-Sun
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Abstract
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Panax ginseng C.A. Meyer has been used as a traditional medicinal ingredient and the ginseng flower-buds also proved to have good medicinal properties. In this study, in order to enhance immune activities of ginseng flower-bud, the ginseng flower-bud extract was being fermented by Bacillus subtilis KCTC 1022 (BS), Lactobacillus plantarum KCTC3 and Saccharomyces cerevisiae strain CHY1011 (SC). Mice were orally administered daily for two weeks at two different concentrations (100 and 200 ㎎/㎏ B.W.). Treatment samples were water extracts of ginseng flower-buds (FD), water extracts of fermented ginseng flower-buds (FM) and controls for saline solution. Cytokine production (IL-6, TNF-α) either stimulated with LPS or not stimulated with LPS was detected by the ELISA assay when using the cytokine kit. Cytokine was statistically increased at supplemented groups with LPS in both the 100 and the 200 ㎎/㎏ B.W. and treatment with FM significantly decreased the LPS-induced TNF-α and IL-6 production more than the treatment with FD. The results of this study may suggest that supplementation with FM increases the immune function by regulating cytokine production capacity for activated macrophages.
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KEYWORD
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IL-6, TNF-α, ginseng flower-bud, fermentation, immune cell
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